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Private military companies (P.M.C.) are a subject that comes about a lot in the news. The crime and terrorism for hire story is a popular and profitable one with a growing business enterprise around the world. The current from hire services in recent times has been very well documented, but largely ignored as a huge subject. The focus is on first responders. These companies are in a lucrative and expanding market. The question say very little about the ultimate cost to human life.
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Category: 2004 live albumsThe role of interleukin-1 (IL-1) in regulation of cyclooxygenase-2 expression in murine peritoneal macrophages.
Cyclooxygenase-2 (COX-2) expression is elevated in many inflammatory conditions. Cytokines such as IL-1alpha, IL-1beta, and TNF-alpha are known to upregulate the expression of COX-2 in some cells. We have used a murine macrophage cell line, RAW 264.7, to study the role of IL-1 in regulating COX-2. We used quantitative reverse transcriptase-polymerase chain reaction and western blotting to show that IL-1beta or IL-1alpha regulates COX-2 expression in RAW 264.7 cells. The COX-2 mRNA level did not change at concentrations up to 10 ng/ml. The COX-2 protein level, however, increased dose dependently, and a maximum of 2-fold increase was detected at 100 ng/ml IL-1beta. Both IL-1beta and IL-1alpha are produced by infiltrating macrophages in the pancreas of the NOD mouse, an animal model of insulin dependent diabetes mellitus (IDDM). In addition, the insulin secretory capacity of these cells was decreased by incubation with IL-1beta. Thus, IL-1beta may be involved in the regulation of both inflammation and the secretory function of insulin-producing cells.Insulin-like growth factor-I induced inhibition of human ovarian surface epithelial cell proliferation is down-regulated by activated PI3K-PKB pathway.
Ovarian tumour formation is associated with excessive expression of insulin-like growth factor-I (IGF-I). A novel link between IGF-I and regulation of proliferation in epithelial ovarian cells was explored in the present study. Human ovarian surface epithelial (HOSE) cells were cultured in serum-free medium and stimulated with exogenous recombinant human IGF-I (rhIGF-I) for 48 h, or for various times (0.5-9 h
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