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Rational Rose Enterprise Edition requires a high performance 64bit processor. Learn more.Genetic instability in prostate cancer cells leads to the maintenance of tumor heterogeneity.
Tumor heterogeneity has been shown to be a major factor accounting for the failure of treatment, but the molecular basis of this heterogeneity remains largely unknown. Here, we showed that elevated mutation rates in the tumor suppressor gene TMPRSS2-ERG fusion, a common event in prostate cancer, were associated with the appearance of clonal variants during tumor progression. We showed that this clonal instability was not associated with a decreased proliferative or migratory capacity but rather increased resistance to treatment and growth in hypoxic conditions. More importantly, we demonstrated that this instability arose from alterations in genomic DNA, thus revealing a novel mechanism driving tumor heterogeneity that may have implication in cancer therapy and other human pathologies.your saved vendors
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Macmillan & Morcom Dance Studio • New Orleans, LA
Macmillan and Morcom Dance Studio, located in Metairie, Louisiana, was established in 1956. Macmillan and Morcom Dance Studio offers a wide variety of ages and dance levels. Individuals and…
Helen S. Sanz/Pro Company
Helen S. Sanz/Pro Company is one of the premier dance companies of New Orleans. Helen S. Sanz/Pro Company, located in Metairie, Louisiana, was established in 1985. Helen S. Sanz/Pro Company…
Jazz & Modern Jazz Band • New Orleans, LA
Called “The Jazz Jazz Band”, by Audubon Magazine, Jazz & Modern Jazz Band brings the excitement and feel of New Orleans to your wedding ceremony or event. We are available for wedding…
Kylie’s Wedding Productions
Kylie and her husband Dustan started their own company, The Kylie
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