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.Q:

What does the phrase “oncogenes” mean?

Can somebody explain what this phrase means?
“A gene which was a proto-oncogene is now oncogene.”

A:

From my dictionary:

Proto-oncogene: a proto-oncogene is a gene that expresses a protein that is itself a regulator of other genes. Proto-oncogenes produce proteins that interact with other proteins and play an important role in regulating cellular growth, differentiation, and development.

A:

A proto-oncogene is a gene that produces a protein that is oncogenic. The prefix pro means “first”. An oncogene is a cancer-causing gene. Cancer is the end product of a tumor, an abnormal mass of cells that grows and spreads.

[Molecularly targeted therapy against breast cancer with HER-2: stabilities of antibodies and enzyme-conjugated anti-HER-2 antibodies].
We investigated the stabilities of various antibodies and enzyme-conjugated anti-HER-2 antibodies under various storage conditions. We found that stabilities of trastuzumab and pertuzumab were decreased by 4 degrees C storage, but remained unchanged by storage at -20 degrees C or -70 degrees C. In contrast, the stability of antibody conjugates of trastuzumab with monomethyl auristatin E (MMAE) or DM1 was drastically reduced at all three temperatures tested. This suggests that stabilities of antibodies and antibody-drug conjugates (ADC) are different. In addition, we found that stabilities of trastuzumab and DM1 conjugates were significantly decreased by heating, yet no change in stability was found for trastuzumab conjugated with anti-PBR-HER-2 mAb ICR62 (DPH12) or for pertuzumab conjugated with anti-HER-2 monoclonal antibody. Stabilities of trastuzumab and pertuzumab were also unaffected by storage at 4 degrees C for 4 or 6 months, suggesting a shelf-life of up to 6 months. Therefore
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