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The functional expression of the B cell antigen receptor (BCR) on mature, resting B cells is under tight regulation of positive and negative signals provided by the B cell antigen receptor (BCR). The CD38 molecule, which is expressed on pre B cells, is not only an enzyme responsible for the synthesis of immunostimulatory nucleotides such as 2,3′-diphospho-5′-adenosine-triphosphate (2,3′-di-ADP), but it also acts as a signal transducer regulating the amount of the BCR on the cell surface of resting B cells. CD38-deficient mice show an arrest of B cell development at the pre B cell stage and the lack of mature B cells in the periphery. In this study, we show that even though B cells from CD38-deficient mice express normal levels of surface Ig and show normal antigen-specific proliferation, they have a selective impairment of their innate immune response compared with wild-type mice as shown in a model of serum IgM (mu) -induced mast cell activation in vitro. In addition, CD38-deficient B cells showed a marked reduction in the induction of apoptosis following anti-mu treatment. These results indicate that CD38 exerts an inhibitory function at the level of the BCR that is not essential for the expression of the BCR but important for the induction of apoptosis in B cells. These findings highlight the importance of CD38 in the maintenance of B cell homeostasis by favoring adaptive, but not innate, immune responses.1930 World Table Tennis Championships – Men’s Doubles

The 1930 World Table Tennis Championships – Men’s Doubles was the second edition of the men’s doubles championship.
Twenty one pairs contested in the double-stage level preliminaries and four pairs competed in the finals.

Results

Stage One

The nine remaining pairs were split into two groups. The top two pairs from each group would play in the second stage. The winners of the second stage matches contested the final.

Group A

Group B

Second

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